[口服15N-甘氨酸的人体利用情况]

[The human utilization of orally administered 15N-glycine].

作者信息

Hartig W, Czarnetzki H D, Faust H, Martin H, Martin R, Wetzel K

出版信息

Infusionsther Klin Ernahr. 1979;6(1):6-9.

Abstract

In 7 convalescent patients we studied utilisation of a single dose of 15N-labelled glycine. In intervals we estimated total-N, urea-N, NH3-N and their 15N-abundances (urine). The following results were obtained. The peak of ammonium-15N appeared 25 minutes earlier than the peak of urea-15 N. The cumulative elimination of total-15N amounted to 25% of uptake after 24 hours and to 34.4% after 6 days. 12 hours after application 53% of the total amount, excreted within 6 days, were already eliminated. 24 hours after administration 80% of total-15N was urea-15N and 2.8% NH3-15N. Further we found correlations between N-balance (N-application minus excretion) and elimination of 15N-urea: If N-balance got more negative, the amount of cumulative elimination, the portion of urea-15N to total-15N and the percentage of elimination after 12 hours related to 6 days were elevated. That means that in stress condition utilisation of glycine to urea is higher and accelerated. The model seems acceptable, to get information concerning metabolic situation in a simple way.

摘要

我们对7名康复患者进行了研究，给予他们单剂量的15N标记甘氨酸。在不同时间段，我们估算了总氮、尿素氮、氨氮及其15N丰度（尿液）。得到以下结果。15N标记铵的峰值比15N标记尿素的峰值早出现25分钟。24小时后，总15N的累积消除量占摄入量的25%，6天后占34.4%。给药12小时后，6天内排出的总量的53%已被消除。给药24小时后，总15N的80%是15N标记尿素，2.8%是15N标记氨。此外，我们发现氮平衡（氮摄入量减去排出量）与15N标记尿素的消除之间存在相关性：如果氮平衡变得更负，累积消除量、15N标记尿素占总15N的比例以及12小时后相对于6天的消除百分比都会升高。这意味着在应激状态下，甘氨酸向尿素的利用率更高且更快。该模型似乎可以接受，能够以简单的方式获取有关代谢状况的信息。