Palva T, Ylikoski J, Mäkinen J
ORL J Otorhinolaryngol Relat Spec. 1978;40(3):129-38. doi: 10.1159/000275397.
Lyophilized dura was utilized in chronic ear surgery to cover raw promontory surfaces, to stabilize the reconstructed ossicles, to raise the posterior insertion point of the grafted drum after canal wall removal, and to fortify the soft posterior canal wall. In 3 guinea pigs, lyodura was also placed in the bulla and studied 6, 12 and 16 months later. In 6 months of time, lyodura had become covered with normal epithelium and in 12 months of time, the greatest part of the lyodura was resorbed from the middle ear, normal epithelium having developed. In the canal wall area, resorption is slower and collagenic dural network is clearly recognizable even after a period of 24 months. Lyophilized dura contains no irritating material and is considered to be a versatile and useful material in chronic ear surgery.
冻干硬脑膜被用于慢性耳科手术，以覆盖鼓岬的粗糙表面、稳定重建的听小骨、在去除外耳道壁后提高移植鼓膜的后插入点，以及加固外耳道后壁。在3只豚鼠中，还将冻干硬脑膜置于鼓泡内，并在6个月、12个月和16个月后进行研究。6个月时，冻干硬脑膜已被正常上皮覆盖，12个月时，中耳内大部分冻干硬脑膜已被吸收，正常上皮已发育形成。在外耳道壁区域，吸收较慢，即使在24个月后，胶原性硬脑膜网络仍清晰可辨。冻干硬脑膜不含刺激性物质，被认为是慢性耳科手术中一种多功能且有用的材料。
