Berger M, Rethy C, Goldberg E
J Am Geriatr Soc. 1979 Apr;27(4):178-82. doi: 10.1111/j.1532-5415.1979.tb06443.x.
Idiopathic hypertrophic subaortic stenosis (IHSS) occurs more commonly in the elderly than is generally believed, and is often unsuspected. In 26 patients above the age of 60, the diagnosis was recognized in only 7 (27 percent) prior to echocardiography. Symptoms included dyspnea in 17, chest pain in 16, and dizziness or syncope in 8 patients. In 10 patients, establishing the correct diagnosis led to therapy with propranolol, with or without discontinuation of digitalis; in 7 of these, the chest pain was significantly reduced. An accurate diagnosis is particularly important because drugs that are useful in other forms of heart disease may have adverse effects in IHSS. Echocardiography is the diagnostic procedure of choice and is indicated in the presence of an unexplained systolic murmur, especially when it is associated with chest pain, syncope or left ventricular hypertrophy.
特发性肥厚性主动脉瓣下狭窄(IHSS)在老年人中的发生率比普遍认为的更高,且常常未被怀疑。在26例60岁以上的患者中,仅7例(27%)在超声心动图检查之前被确诊。症状包括17例呼吸困难、16例胸痛以及8例头晕或晕厥。10例患者在确诊后接受了普萘洛尔治疗,部分患者停用了洋地黄;其中7例患者的胸痛症状明显减轻。准确诊断尤为重要,因为对其他形式心脏病有效的药物在IHSS中可能产生不良反应。超声心动图是首选的诊断方法,当出现无法解释的收缩期杂音时应进行检查,尤其是当杂音与胸痛、晕厥或左心室肥厚相关时。