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A possible neuronal release of [14C] GABA from the rat cerebellum in vivo.

作者信息

Davidson N, Bernardi N, Fawcett M, Wong E, Assumpção J A, Dacke C G

出版信息

Pflugers Arch. 1979 Mar 16;379(2):149-55. doi: 10.1007/BF00586941.

DOI:10.1007/BF00586941
PMID:571109
Abstract

Release patterns for exogenously applied [14C] labelled alpha-amino-n-butyric-acid (GABA) have been investigated in rat cerebellar cortex in vivo. An increase in [14C] GABA release could be evoked by stimulating with high (40 mM) K+ or veratridine (10(-4)M) but not with direct electrical stimulation. Biphasic patterns for high K+ and possibly veratridine stimulated release of GABA suggest the existence of two separate anatomical sources of isotope which are sensitive to these depolarising stimuli. Both K+ and veratridine-evoked GABA release are calcium dependent. Studies involving partial replacement of Na+ with HEPES, (N-2-hydroxyethyl-piperazine-N-2-ethane-sulphonic acid), sucrose or choline chloride also reveal a sodium dependency of [14C] GABA release. These studies collectively indicate a neuronal source for evoked GABA release, a criterion for transmitter identification not previously satisfied in the cerebellar cortex.

摘要

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本文引用的文献

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Metabolic properties of a purified preparation of large fragments of the cerebellar glomeruli: glucose metabolism and amino acid uptake.小脑小球大碎片纯化制剂的代谢特性：葡萄糖代谢和氨基酸摄取。
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Proceedings: Selective autoradiographic markers for GABA-releasing interneurones and nerve terminals.论文集：用于释放γ-氨基丁酸的中间神经元和神经末梢的选择性放射自显影标记物
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