对氨基比林所致过敏性粒细胞缺乏症的血清学研究。

Serological study of an allergic agranulocytosis due to noramidopyrine.

作者信息

Magis C C, Barge A, Dausset J

出版信息

Clin Exp Immunol. 1968 Nov;3(9):989-1003.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1579012/

Abstract

An allergic agranulocytosis induced by amidopyrine and triggered by noramidopyrine was studied. Leucoagglutinating and leucocytotoxic antibody, active only in the presence of the drug, was demonstrated. The antibody was stable, giving a titre from 1·34 to 1·62 and was present in the IgM (19S globulin) and in the IgG (7S globulin) serum fractions. The site of drug fixation was studied by use of iodoantipyrine labelled with I; a stable fixation was demonstrated on to the IgM and IgG globulins. Special emphasis is given to cross-reaction with compounds related to amidopyrine.

摘要

对由氨基比林诱发、去甲氨基比林引发的过敏性粒细胞缺乏症进行了研究。发现了仅在药物存在时才具有活性的白细胞凝集和白细胞毒性抗体。该抗体稳定，效价为1·34至1·62，存在于IgM（19S球蛋白）和IgG（7S球蛋白）血清组分中。通过使用用碘标记的碘安替比林研究了药物固定部位；证明其能稳定地固定在IgM和IgG球蛋白上。特别强调了与氨基比林相关化合物的交叉反应。

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