Wiik A, Munthe E
Immunology. 1974 Jun;26(6):1127-34.
Forty-one sera from patients with rheumatoid arthritis (RA) and accompanying neutropenia, including twenty-one with Felty's syndrome, were studied to investigate the occurrence and determine the titres of granulocyte-specific antinuclear factors (GS-ANF) belonging to the three main immunoglobulin classes. Furthermore complement (C3) fixing GS-ANF and rheumatoid factors were titrated in the sera. Complement-fixing GS-ANF were found in thirty-five of these sera compared with only four out of twenty-eight sera from RA patients without neutropenia. Complement-fixing GS-ANF were similarly detected in all of six sera from non-arthritic patients with severe neutropenia and positive Waaler—Rose tests. Complement-fixing properties of the antibodies were mostly found in sera containing high titres of GS-ANF of the IgG and IgM classes, but the titres of complement-fixing GS-ANF were on the whole markedly lower than the corresponding IgG and IgM antibody titres. A direct autoaggressive activity of complement-fixing GS-ANF on the neutrophilic granulocytes or their precursors is suggested.
对41例患有类风湿性关节炎（RA）并伴有中性粒细胞减少症的患者血清进行了研究，其中包括21例患有费尔蒂综合征的患者，以调查粒细胞特异性抗核因子（GS-ANF）属于三种主要免疫球蛋白类别的发生率并确定其滴度。此外，还对血清中的补体（C3）结合GS-ANF和类风湿因子进行了滴定。在这些血清中有35例检测到补体结合GS-ANF，而在28例无中性粒细胞减少症的RA患者血清中只有4例检测到。在6例患有严重中性粒细胞减少症且瓦勒-罗斯试验呈阳性的非关节炎患者的所有血清中也同样检测到补体结合GS-ANF。抗体的补体结合特性大多在含有高滴度IgG和IgM类GS-ANF的血清中发现，但补体结合GS-ANF的滴度总体上明显低于相应的IgG和IgM抗体滴度。提示补体结合GS-ANF对嗜中性粒细胞或其前体具有直接的自身攻击活性。
