Berger H M, Scott P H, Kenward C, Scott P, Wharton B A
Arch Dis Child. 1979 Feb;54(2):98-104. doi: 10.1136/adc.54.2.98.
Some animals thrive more satisfactorily on a milk that contains whey and curd protein. For this reason human milk protein (which contains about 40% whey) may have some advantages over cows' milk protein (which contains about 15% whey) and so infants feeding formulae based on demineralised whey in which the protein has been modified to achieve a curd:whey ratio similar to that in human milk may also thrive more satisfactorily. As the exact situation in the human newborn is unclear, the effects of feeding a formula containing unmodified cows' milk protein (mainly curd) and one containing the same amount of modified cows' milk protein (curd and whey) were studied in 57 low birthweight babies during the first 3 months of life. During the early weeks of life the curd and whey group grew bigger, absorbed more nitrogen, and excreted proportionately less urea. These results suggest that a curd and whey formula has advantages in the protein nutrition of low birthweight babies, especially the preterm ones. We feel it would be unwise to reduce the protein content of a formula based on cows' milk below 15 g/1 unless it was modified to achieve a larger proportion of whey protein and hence, among other qualities, more cysteine. Although some of the qualities of human milk protein can be mimicked by the use of demineralised whey formulae, others cannot.
有些动物食用含乳清蛋白和酪蛋白的牛奶时生长得更理想。因此，人乳蛋白（含约40%乳清蛋白）可能比牛乳蛋白（含约15%乳清蛋白）具有某些优势，所以以脱矿质乳清为基础、其中蛋白质已被改良以达到与人乳相似的凝乳与乳清比例的婴儿配方奶粉，婴儿食用后可能也会生长得更理想。由于人类新生儿的确切情况尚不清楚，因此在57名低体重儿出生后的头3个月里，研究了分别喂食含未改良牛乳蛋白（主要是酪蛋白）的配方奶粉和含等量改良牛乳蛋白（酪蛋白和乳清蛋白）的配方奶粉的效果。在生命的最初几周里，酪蛋白和乳清蛋白组婴儿长得更大，吸收了更多的氮，且尿素排泄量相对较少。这些结果表明，酪蛋白和乳清蛋白配方奶粉在低体重儿尤其是早产儿的蛋白质营养方面具有优势。我们认为，将基于牛奶的配方奶粉蛋白质含量降至15克/升以下是不明智的，除非对其进行改良以增加乳清蛋白的比例，从而在其他特性中含有更多的半胱氨酸。尽管使用脱矿质乳清配方奶粉可以模拟人乳蛋白的某些特性，但其他特性则无法模拟。
