通过对供体进行抗淋巴细胞血清治疗来改变移植物抗宿主综合征。
Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the donor.
作者信息
Boak J L, Wilson R E
出版信息
Clin Exp Immunol. 1968 Oct;3(8):795-800.
Abstract
Spleen and lymph node suspensions prepared from parental donor mice pretreated with four daily anti-lymphocyte serum (ALS) injections have been demonstrated to be incapable of inducing a graft--host (GVH) syndrome when injected into F hybrid recipient mice. A single ALS injection to the parental donor renders thoracic duct lymphocytes incapable of inducing a GVH response but the activity of spleen cell suspensions is retained. It is suggested that this observation supports the view that ALS acts mainly on circulating lymphocytes.
摘要
从每天接受四次抗淋巴细胞血清（ALS）注射预处理的亲代供体小鼠制备的脾脏和淋巴结悬液，已证明当注入F1杂种受体小鼠时，不能诱导移植物抗宿主（GVH）综合征。对亲代供体单次注射ALS会使胸导管淋巴细胞无法诱导GVH反应，但脾细胞悬液的活性得以保留。有人认为，这一观察结果支持了ALS主要作用于循环淋巴细胞的观点。
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