Karpatkin S, Fotino M, Gibofsky A, Winchester R J
J Clin Invest. 1979 May;63(5):1085-8. doi: 10.1172/JCI109378.
Peripheral blood lymphocytes from 38 patients with autoimmune thrombocytopenic purpura (AITP) were tested for HLA-A, -B, and -C alloantigens. Isolated B lymphocytes from 20 of these patients were tested for HLA-DRw (Ia) alloantigens. The profile of HLA alloantigens in the patients with AITP was significantly different from that of a matched control population. The most significant finding was the presence of the HLA-DRw2 alloantigen in 75% of patients as compared with 23% in the control population, P less than 0.001, relative risk 10.0 (A relative risk of 1 would indicate no association between the presence of the antigen and the disease.) The co-occurrence of either A3 and B7 (known to be in linkage disequilibrium with DRw2) or A26 and Bw38 was significantly increased as compared with the control population (P less than 0.001). Of the patients positive for DRw2, 47% had the association A26 and Bw38 as compared with the control population association incidence of 21% (P less than 0.1). Thus, in the patient population, A26-Bw38 appears to be a haplotype that is in linkage disequilibrium with DRw2 (as presumably is the case with A3-B7). These data indicate that a predisposition to AITP is inherited with a DRw2 gene of the major histocompatibility system.
对38例自身免疫性血小板减少性紫癜（AITP）患者的外周血淋巴细胞进行了HLA - A、- B和 - C同种抗原检测。对其中20例患者分离出的B淋巴细胞进行了HLA - DRw（Ia）同种抗原检测。AITP患者的HLA同种抗原谱与匹配的对照人群有显著差异。最显著的发现是，75%的患者存在HLA - DRw2同种抗原，而对照人群中这一比例为23%，P小于0.001，相对风险为10.0（相对风险为1表明抗原的存在与疾病之间无关联）。与对照人群相比，A3和B7（已知与DRw2处于连锁不平衡状态）或A26和Bw38的共出现显著增加（P小于0.001）。在DRw2阳性的患者中，47%具有A26和Bw38的关联，而对照人群的关联发生率为21%（P小于0.1）。因此，在患者群体中，A26 - Bw38似乎是一种与DRw2处于连锁不平衡状态的单倍型（推测A3 - B7也是如此）。这些数据表明，AITP的易感性是通过主要组织相容性系统的DRw2基因遗传的。
