Ansari Z, Singh K S
J Helminthol. 1978 Dec;52(4):287-90. doi: 10.1017/s0022149x00005502.
The results of vaccination trial in lambs with gamma-irradiated infective larvae of Gaigeria pachyscelis are described. A single percutaneous (P/C) vaccination of lambs with 2000 infective larvae irradiated at 40 Kr induced the development of resistance. The vaccinated lambs successfully resisted a lethal challenge infection of 5000 non-irradiated larvae 3 months later. In the vaccinated lambs, the manifestations of resistance were shown by marked reduction in the worm establishment, development of retarded and functionally sterile worms and absence of clinical signs of hookworm disease after the challenge infection.
本文描述了用伽马射线辐照的粗厚盖尾线虫感染性幼虫对羔羊进行疫苗接种试验的结果。用40千拉德辐照的2000条感染性幼虫对羔羊进行单次经皮（P/C）接种，可诱导产生抗性。3个月后，接种疫苗的羔羊成功抵抗了5000条未辐照幼虫的致死性攻击感染。在接种疫苗的羔羊中，抗性表现为虫体定植显著减少、发育迟缓且功能不育的虫体出现，以及攻击感染后没有钩虫病的临床症状。
