Driessen G K, Heidtmann H, Schmid-Schönbein H
Pflugers Arch. 1979 May 15;380(1):1-6. doi: 10.1007/BF00582604.
Erythrocyte velocities in capillaries of rat mesentery were measured during systemic normotension and hypotension over a range of hematocrit from 0.31 +/- 0.06 to 0.58 +/- 0.04. Velocity was measured according to the method of Tompkins, Monti and Intaglietta. The hematocrit was varied by isovolemic exchange of blood with 4.5 g% albumin solution (bovine) or packed red cells (Hct. approximately 0.9). Hypotension was induced by hemorrhage to a preselected pressure of about 35 mm Hg. Under normotension red cell velocity stayed almost constant over a range of Hct. from 0.31 +/- 0.07 to 0.58 +/- 0.09. However, during hypotension significant differences were found for control animals (Hct. 0.43 +/- 0.07), hemodiluted animals (Hct. 0.31 +/- 0.06), and hemoconcentrated animals (Hct. 0.58 +/- 0.04). Velocities amounted to 36 +/- 21%, 52 +/- 24%, and 29 +/- 27% respectively, compared to control velocity. These marked differences in red cell velocities are explained by the strong effect of the hematocrit levels on apparent blood viscosities. It is assumed that the post-capillary microvascular bed is the site where the hematocrit level will affect apparent blood viscosity most intensively.
在全身正常血压和低血压状态下，于大鼠肠系膜毛细血管中测量红细胞速度，血细胞比容范围为0.31±0.06至0.58±0.04。速度根据汤普金斯、蒙蒂和因塔利亚塔的方法进行测量。通过用4.5 g%白蛋白溶液（牛）或浓缩红细胞（血细胞比容约为0.9）进行等容血液交换来改变血细胞比容。通过出血将血压降至预先选定的约35 mmHg的压力来诱导低血压。在正常血压下，红细胞速度在血细胞比容为0.31±0.07至0.58±0.09的范围内几乎保持恒定。然而，在低血压期间，发现对照动物（血细胞比容0.43±0.07）、血液稀释动物（血细胞比容0.31±0.06）和血液浓缩动物（血细胞比容0.58±0.04）之间存在显著差异。与对照速度相比，速度分别为36±21%、52±24%和29±27%。红细胞速度的这些显著差异是由血细胞比容水平对表观血液粘度的强烈影响所解释的。据推测，毛细血管后微血管床是血细胞比容水平对表观血液粘度影响最强烈的部位。
