• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The concentrations of orphenadrine and its N-demethylated derivatives in rat brain, after intraperitoneal administration of orphenadrine and tofenacine.

作者信息

Roozemond R C, Hespe W, Nauta W T

出版信息

Int J Neuropharmacol. 1968 May;7(3):293-300. doi: 10.1016/0028-3908(68)90036-1.

DOI:10.1016/0028-3908(68)90036-1
PMID:5720519
Abstract
摘要

相似文献

1
The concentrations of orphenadrine and its N-demethylated derivatives in rat brain, after intraperitoneal administration of orphenadrine and tofenacine.腹腔注射邻甲苯海明和托芬那辛后，大鼠脑中邻甲苯海明及其N-去甲基化衍生物的浓度。
Int J Neuropharmacol. 1968 May;7(3):293-300. doi: 10.1016/0028-3908(68)90036-1.
2
Aspects of the biliary excretion of orphenadrine and its N-demethylated derivative, tofenacin, in the rat.去痛片及其N-去甲基衍生物托芬那辛在大鼠体内的胆汁排泄情况。
Eur J Pharmacol. 1970;13(1):113-22. doi: 10.1016/0014-2999(70)90191-3.
3
Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat.在大鼠体内单-N-去甲基邻甲苯海明（托非那辛）代谢过程中形成稳定的细胞色素P-450代谢中间复合物，导致邻甲苯海明代谢出现产物抑制现象。
Res Commun Chem Pathol Pharmacol. 1983 Jun;40(3):391-403.
4
Metabolism of orphenadrine citrate in man.
J Pharmacol Exp Ther. 1971 Feb;176(2):284-95.
5
Metabolic studies of 3 H-orphenadrine citrate in the rat, dog and rhesus monkey.
Arch Int Pharmacodyn Ther. 1972 Feb;195(2):213-30.
6
Serotonin depletion induced by reserpine is attenuated by prophylactic administration of lithium.利血平诱导的血清素耗竭可通过预防性给予锂来减轻。
Eur J Pharmacol. 1985 Jul 17;113(2):225-31. doi: 10.1016/0014-2999(85)90739-3.
7
Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.多次给予奥芬那君或单-N-去甲基奥芬那君对大鼠细胞色素P-450催化反应的影响。
Arch Toxicol. 1983 Oct;54(2):131-7. doi: 10.1007/BF01261381.
8
Distribution of tritium-labelled tofenacine hydrochloride in the pregnant mouse.氚标记盐酸托芬那辛在妊娠小鼠体内的分布
Eur J Pharmacol. 1969 Oct;8(1):119-26. doi: 10.1016/0014-2999(69)90137-x.
9
Distribution of [14C]-tofenacine in rat brain after intravenous, intraperitoneal and multiple oral dosage.
Arzneimittelforschung. 1975;25(12):1910-5.
10
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.苯巴比妥与盐酸奥芬那君及盐酸托芬那辛在幼鼠和成年大鼠中酶诱导活性的比较。
Arch Int Pharmacodyn Ther. 1973 Oct;205(2):213-7.

引用本文的文献

1
Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man.
Eur J Clin Pharmacol. 1982;21(4):343-50. doi: 10.1007/BF00637624.