An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats.

Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.