Kokkinidis L, Kirkby R D, McCarter B D, Borowski T B
Department of Psychology, University of Saskatchewan, Saskatoon, Canada.
Life Sci. 1989;44(9):633-41. doi: 10.1016/0024-3205(89)90196-3.
The exacerbation of the locomotor and stereotypic effects of amphetamine after repeated drug administration is well documented. To elaborate on the involvement of the nigrostriatal and mesolimbic dopamine (DA) systems in modulating behavioral sensitization, locomotor activity and the time spent engaged in repetitive stereotyped behaviors following systemic amphetamine injection were assessed after electrical stimulation of the nucleus accumbens and neostriatum. It was found that exposure to repeated sessions of high frequency, low current stimulation of the anteromedial neostriatum and nucleus accumbens significantly enhanced the locomotor excitation induced by administration of 3.0 mg/kg of amphetamine. Stereotypic behaviors were also modified as a function of electrical stimulation of these brain regions, with the development of a significant decrease in the duration of focused head and body movements corresponding to the facilitated locomotor effects of the drug. Taken together, these data provide additional evidence demonstrating the interdependent relationship between amphetamine-elicited locomotor activity and stereotypy, and were discussed in terms of a functional interaction between mesolimbic and nigrostriatal systems in determining the behavioral profile of amphetamine administration.
反复给药后苯丙胺运动和刻板效应的加剧已有充分记录。为详细阐述黑质纹状体和中脑边缘多巴胺（DA）系统在调节行为敏化中的作用，在电刺激伏隔核和新纹状体后，评估了全身注射苯丙胺后的运动活动以及从事重复性刻板行为所花费的时间。结果发现，暴露于高频、低电流刺激前内侧新纹状体和伏隔核的重复刺激中，显著增强了3.0mg/kg苯丙胺给药诱导的运动兴奋。刻板行为也因这些脑区的电刺激而改变，与药物促进的运动效应相对应，集中的头部和身体运动持续时间显著减少。综上所述，这些数据提供了额外的证据，证明了苯丙胺诱发的运动活动和刻板行为之间的相互依赖关系，并根据中脑边缘系统和黑质纹状体系统在确定苯丙胺给药行为特征方面的功能相互作用进行了讨论。
