卵巢切除术及注射苯甲酸雌二醇对下丘脑多肽代谢的影响。
The effects of ovariectomy and injected oestradiol monobenzoate on polypeptide metabolism in the hypothalamus.
作者信息
Hooper K C
出版信息
Biochem J. 1968 Nov;110(1):151-3. doi: 10.1042/bj1100151.
Abstract
- The activities of two groups of peptidases separated from a homogenate of rabbit hypothalamus were determined (a) in adult female animals, (b) in ovariectomized animals and (c) in intact female animals after injection of oestradiol monobenzoate (15-120mug.). 2. Ovariectomy decreased the enzyme activity initially; the activity in the particulate group of enzymes subsequently returned to normal whereas the activity of the supernatant fraction was less than normal 8 months after operation. 3. Injection of oestradiol monobenzoate increased the enzyme activity in the supernatant fraction to that observed in pregnant animals and in suckled lactating animals. 4. There is a correlation between changes in enzyme activity of the supernatant fraction and conditions that are known to influence gonadotrophin secretion.
摘要
- 测定了从兔下丘脑匀浆中分离出的两组肽酶的活性：(a) 在成年雌性动物中；(b) 在去卵巢动物中；(c) 在注射单苯甲酸雌二醇（15 - 120微克）后的完整雌性动物中。2. 去卵巢最初会降低酶活性；颗粒酶组的活性随后恢复正常，而手术后8个月，上清液部分的活性低于正常水平。3. 注射单苯甲酸雌二醇使上清液部分的酶活性增加到在怀孕动物和哺乳动物中观察到的水平。4. 上清液部分酶活性的变化与已知影响促性腺激素分泌的条件之间存在相关性。
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