Buchanec J, Visnovský P, Buchancová J, Cervenáková E
Klin Padiatr. 1979 May;191(3):301-4.
Acetylsalicylic acid in a single dose of 10 mg/kg orally affected the skin temperature of the hand of febrile and afebrile children. In the afebrile group the rise of skin temperature after 1 hour (p less than 0,05) and 2 hours (p less than 0.01) was not accompanied by significant change of the sublingual or axillar temperature. In the febrile group the rise of the skin temperature of the 3rd finger after 1 hour (p less than 0,001) and 2 hours (p less than 0.001) was accompanied by a significant decrease of the sublingual and axillar temperature and by a decrease of pulse rate. The changes were more pronounced after 1 hour after administration of the drug. Similarly, the acetylsalicylic acid enhanced the relative blood flow through the skin of the finger of hand.
口服单剂量10毫克/千克的乙酰水杨酸会影响发热和未发热儿童手部的皮肤温度。在未发热组中，1小时（p＜0.05）和2小时（p＜0.01）后皮肤温度升高，同时舌下或腋窝温度无显著变化。在发热组中，给药1小时（p＜0.001）和2小时（p＜0.001）后，第三指皮肤温度升高，同时舌下和腋窝温度显著下降，心率降低。给药1小时后这些变化更为明显。同样，乙酰水杨酸会增加通过手部手指皮肤的相对血流量。
