Species difference in diazepam metabolism and anticonvulsant effect.

Suppr

超能文献

作者信息

Marcucci F, Guaitani A, Kvetina J, Mussini E, Garattini S

出版信息

Eur J Pharmacol. 1968 Nov;4(4):467-70. doi: 10.1016/0014-2999(68)90036-8.

DOI:10.1016/0014-2999(68)90036-8

PMID:5724923

Abstract

摘要

相似文献

Species difference in diazepam metabolism and anticonvulsant effect.

Eur J Pharmacol. 1968 Nov;4(4):467-70. doi: 10.1016/0014-2999(68)90036-8.

A metabolic explantation for differences between species of the anticonvulsant activity of diazepam.地西泮抗惊厥活性种间差异的代谢外植体研究。

Br J Pharmacol. 1968 Nov;34(3):667P-668P.

Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.

Biochem Pharmacol. 1970 Feb;19(2):363-79. doi: 10.1016/0006-2952(70)90192-9.

Metabolism and anticonvulsant activity of diazepam in guinea pigs.地西泮在豚鼠体内的代谢及抗惊厥活性

Biochem Pharmacol. 1971 Jul;20(7):1711-3. doi: 10.1016/0006-2952(71)90304-2.

Anticonvulsant potency of unmetabolized diazepam.

Pharmacology. 1982;25(3):154-9. doi: 10.1159/000137737.

Anticonvulsant activity and brain levels of diazepam and its metabolites in mice.小鼠体内地西泮及其代谢物的抗惊厥活性和脑内水平

Eur J Pharmacol. 1971 Nov-Dec;16(3):311-4. doi: 10.1016/0014-2999(71)90032-x.

Studies on the anticonvulsant action of diazepam.地西泮抗惊厥作用的研究。

Br J Pharmacol. 1970 Feb;38(2):455P-457P.

Further studies on species difference in diazepam metabolism.地西泮代谢物种差异的进一步研究。

Eur J Pharmacol. 1970 Feb;9(2):253-6. doi: 10.1016/0014-2999(70)90308-0.

Brain concentrations of lorazepam and oxazepam at equal degree of anticonvulsant activity.

J Pharm Pharmacol. 1972 Jan;24(1):63-4. doi: 10.1111/j.2042-7158.1972.tb08865.x.

Further studies on the long lasting antimetrazol activity of diazepam in mice.地西泮对小鼠的长效抗惊厥活性的进一步研究。

Eur J Pharmacol. 1970 Jul 1;11(1):115-6. doi: 10.1016/0014-2999(70)90262-1.

引用本文的文献

Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments.耐药性癫痫的动物模型作为破译药物抵抗的细胞和分子机制以及发现更有效的治疗方法的工具。

Cells. 2023 Apr 24;12(9):1233. doi: 10.3390/cells12091233.

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.测定安定引起大鼠惊厥阈升高的最小稳态血药浓度。

Epilepsia. 2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6.

Intranasal delivery--modification of drug metabolism and brain disposition.鼻腔给药——改变药物代谢和脑内分布。

Pharm Res. 2010 Jul;27(7):1208-23. doi: 10.1007/s11095-010-0127-5. Epub 2010 Apr 6.

Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios.开发一个基于生理学的全身模型以表征苯二氮䓬类药物的药代动力学。1：大鼠组织-血浆分配比的估算

J Pharmacokinet Pharmacodyn. 2004 Aug;31(4):269-98. doi: 10.1023/b:jopa.0000042737.14033.c6.

Species differences in phenazepam kinetics and metabolism.芬那西泮动力学与代谢的种属差异。

Eur J Drug Metab Pharmacokinet. 1982;7(3):191-6. doi: 10.1007/BF03189565.

Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-,1,5-benzodiazepine-4-one) in the rat and mouse.CP 1414 S（7-硝基-2-氨基-5-苯基-3-H-，1,5-苯并二氮杂卓-4-酮）在大鼠和小鼠体内的抗惊厥活性及动力学

Eur J Drug Metab Pharmacokinet. 1982;7(2):93-7. doi: 10.1007/BF03188724.

Ro 15-1788 is a potent antagonist of benzodiazepines in the olfactory cortex slice.Ro 15-1788是嗅皮质切片中苯二氮䓬类药物的强效拮抗剂。

Pflugers Arch. 1983 Mar;396(4):292-6. doi: 10.1007/BF01063933.

Anticonvulsant drugs. An update.抗惊厥药物。最新进展。

Drugs. 1984 Apr;27(4):328-63. doi: 10.2165/00003495-198427040-00003.

Diazepam increases GABA mediated inhibition in the olfactory cortex slice.地西泮增强了嗅皮质切片中γ-氨基丁酸（GABA）介导的抑制作用。

Pflugers Arch. 1983 Jun 1;397(4):312-8. doi: 10.1007/BF00580267.

Antidepressants and tranquillizers: biochemical aspects.抗抑郁药与镇静剂：生化方面

Humangenetik. 1970;9(3):202-4. doi: 10.1007/BF00279213.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验