Lewis E D, Griggs R C, Moxley R T
Neurology. 1979 Aug;29(8):1131-7. doi: 10.1212/wnl.29.8.1131.
Hyperkalemic periodic paralysis is frequently considered a disorder in which episodes of weakness and an attendant rise in plasma potassium interrupt a baseline of normal strength and potassium. We studied venous potassium throughout a 36-hour period in two patients with hyperkalemic periodic paralysis and in nine normals under rigidly controlled conditions. At no time did the patients with periodic paralysis have an attack of weakness, but their mean potassium concentrations were above the normal range for 33 to 36 hours. In hyperkalemic periodic paralysis, the postprandial change in potassium relative to insulin release exceeded normal. There appears to be a continuous alteration in potassium regulation in our patients with hyperkalemic periodic paralysis.
高钾性周期性麻痹常被视为一种疾病，其特征为肌无力发作以及随之而来的血浆钾升高，打断了正常肌力和钾水平的基线状态。我们在严格控制的条件下，对两名高钾性周期性麻痹患者和九名正常人在36小时内的静脉血钾进行了研究。周期性麻痹患者在任何时候都未出现肌无力发作，但其平均血钾浓度在33至36小时内高于正常范围。在高钾性周期性麻痹中，餐后钾相对于胰岛素释放的变化超过正常水平。我们的高钾性周期性麻痹患者似乎存在钾调节的持续改变。
