人类细胞中的嘧啶二聚体切除与皮肤癌
Pyrimidine dimer excision in human cells and skin cancer.
作者信息
Regan J D, Carrier W L, Smith D P, Waters R, Lee W H
出版信息
Natl Cancer Inst Monogr. 1978 Dec(50):141-3.
PMID:572917
Abstract
We compared three methods for estimating the induction and removal of UV-induced pyrimidine dimers from the DNA of human fibroblasts. Results indicate that after UV doses of 5-20 J/m2, 50% of the dimers are removed by 24 hours. Almost complete excision can be observed if the cells are incubated for periods not less than 72 hours after a dose of 5 J/m2. After higher doses, it probably takes even longer for such complete removal to doses, it probably takes even longer for such complete removal to be seen.
摘要
我们比较了三种估算从人成纤维细胞DNA中诱导和去除紫外线诱导嘧啶二聚体的方法。结果表明，紫外线剂量为5-20 J/m²后，50%的二聚体在24小时内被去除。如果细胞在5 J/m²剂量后孵育不少于72小时，可以观察到几乎完全切除。在更高剂量后，可能需要更长时间才能看到这种完全去除。
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