Neely D P, Stabenfeldt G H, Kindahl H, Hughes J P, Kendrick J W
Am J Vet Res. 1979 May;40(5):665-8.
The intrauterine infusion of 500 ml of warm sterile saline solution into mares on days 12, 13, or 14 after ovulation failed to alter the ovulatory interval, although intervals were shorter for days 12 and 13 (20.6 days) when compared with those in control mares (21.6 days). The IU fusion shortened luteal-life-span on days 12 (12.0 vs 13.8 days) and 13 (13.0 vs 14.4 days) (P is less than 0.05), but not day 14 (14.0 vs 13.5 days), when comparing the effects of IU infusion with an average of before and after base-line data. There was no effect on the interval from corpus luteum regression to ovulation, ie, the final follicular phases. The treatment average for days 12 and 13 combined was 7.7 days vs 7.3 days for controls. Also, no significant effect was observed for the duration of estrus in that the treatment average for days 12 and 13 was 5.1 days, and for controls, 6.0 days. The infusion of saline solution caused an immediate release of prostaglandin F(2alpha) within 5 minutes, with additional large releases occurring over the next 24 hours. Progestin concentrations decreased rapidly in relation to this prostaglandin release.
在排卵后第12、13或14天，向母马子宫内注入500毫升温热无菌盐溶液，未能改变排卵间隔，不过与对照母马（21.6天）相比，第12天和第13天的间隔较短（20.6天）。与基线数据前后平均值相比，子宫内注入（IU）在第12天（12.0天对13.8天）和第13天（13.0天对14.4天）缩短了黄体期（P小于0.05），但在第14天没有（14.0天对13.5天）。对从黄体退化到排卵的间隔，即最终卵泡期没有影响。第12天和第13天合并的治疗平均值为7.7天，而对照为7.3天。此外，发情持续时间没有观察到显著影响，第12天和第13天的治疗平均值为5.1天，对照为6.0天。注入盐溶液导致在5分钟内立即释放前列腺素F（2α），在接下来的24小时内还会有额外的大量释放。孕酮浓度相对于这种前列腺素释放迅速下降。
