Wilson S R
Ann Hum Genet. 1979 May;42(4):513-22. doi: 10.1111/j.1469-1809.1979.tb00684.x.
In this article we reconsider the analysis proposed by Reich et al. (1972) for determining the mode of inheritance for semi-continuous traits from intrafamilial data. We consider both the (general) multifactorial and the single-locus model formulation. We show (numerically), by using a much improved numerical analysis technique for the parameter estimation, that there may be many single-locus models that could have given rise to a particular data set, dependent on its size and nature. Finally we question whether the use of monozygotic twins data, or data obtained from defining further levels of severity of the disease, would improve the discrimination between these two types of models.
在本文中，我们重新审视了赖希等人（1972年）提出的用于从家族内数据确定半连续性状遗传模式的分析方法。我们考虑了（一般的）多因素模型和单基因座模型公式。通过使用一种大大改进的用于参数估计的数值分析技术，我们（从数值上）表明，根据特定数据集的大小和性质，可能有许多单基因座模型能够产生该数据集。最后，我们质疑使用同卵双胞胎数据或通过定义疾病更严重程度级别获得的数据，是否会改善这两种模型之间的区分。
