Merriam G R, Nunnelley L L, Trish J W, Naftolin F
Brain Res. 1979 Aug 10;171(3):503-10. doi: 10.1016/0006-8993(79)91054-0.
The concentrations of 7 trace elements--iron, copper, zinc, arsenic, selenium, bromine, and rubidium--in rat hypothalami and anterior pituitaries were measured by X-ray fluorescence spectrometry. Male, cycling female, and oophorectomized animals were studied under different conditions of reproductive function. Hypothalamic zinc and copper concentrations both rose between proestrus and estrus days and fell again at diestrus. After castration, concentrations of iron, copper, and arsenic were decreased in both pituitary and hypothalamus, while zinc concentrations rose. Male rats had lower pituitary concentrations of iron, copper, zinc, arsenic, and rubidium than cycling females. Under these hormonal manipulations, hypothalamus zinc concentration and gonadotropin secretion appear to be correlated. While injections of copper salts into the hypothalamus can also stimulate gonadotropin release, we did not observe any consistent relation between endogenous hypothalamic copper concentrations and gonadotropins.
采用X射线荧光光谱法测定了大鼠下丘脑和垂体前叶中7种微量元素——铁、铜、锌、砷、硒、溴和铷的浓度。对处于不同生殖功能状态的雄性、处于发情周期的雌性以及去卵巢动物进行了研究。下丘脑锌和铜的浓度在动情前期和发情期之间均升高，在动情间期又再次下降。阉割后，垂体和下丘脑中铁、铜和砷的浓度均降低，而锌浓度升高。雄性大鼠垂体中铁、铜、锌、砷和铷的浓度低于处于发情周期的雌性大鼠。在这些激素调控下，下丘脑锌浓度与促性腺激素分泌似乎相关。虽然向下丘脑注射铜盐也能刺激促性腺激素释放，但我们未观察到内源性下丘脑铜浓度与促性腺激素之间存在任何一致的关系。
