Thorlacius-Ussing O, Gregersen M, Hertel N
Institute of Anatomy (Neurobiology), University of Aarhus, Denmark.
Biol Trace Elem Res. 1988 Aug;16(3):189-202. doi: 10.1007/BF02797135.
The concentration of twelve elements--potassium, calcium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, selenium, bromine, and rubidium--in anterior pituitaries from human subjects and rats was measured using Particle Induced X-ray Emission (PIXE). The human material included anterior pituitaries from 37 normal human subjects, 27 males and 10 females, all of whom died from traumatic lesions. Excluded from the investigations were persons with alcohol abuse, regular use of drugs, and babies younger than 1 year. For selenium, zinc, bromine, and to some extent copper, there was good correlation between the amounts found in anterior pituitaries from rats and human subjects. A significant difference between male and female rat pituitaries was observed for copper, iron, and rubidium, whereas for humans significant difference was only observed for manganese. Anterior pituitaries from human females contained generally more zinc than male glands, but the concentration of zinc in young males was higher than in females. The present study also indicates age related differences in the copper content in anterior pituitaries from human subjects, since pituitaries from humans between 15-45 years contained 25% more copper than those from younger or older persons. The opposite pattern was observed in males. For such elements as Cu, Fe, Mn, and Se, the content in the anterior pituitary from human subjects was 1.6-2 times that stated for other endocrine organs.
采用粒子激发X射线发射（PIXE）技术测定了人体和大鼠垂体前叶中12种元素——钾、钙、锰、铁、钴、镍、铜、锌、砷、硒、溴和铷的浓度。人体样本包括37名正常受试者的垂体前叶，其中男性27名，女性10名，均死于外伤。研究排除了酗酒、经常使用药物的人以及1岁以下的婴儿。对于硒、锌、溴以及在一定程度上的铜，大鼠和人体垂体前叶中这些元素的含量之间存在良好的相关性。在大鼠垂体前叶中，观察到铜、铁和铷在雄性和雌性之间存在显著差异，而在人体中，仅观察到锰存在显著差异。人体女性的垂体前叶通常比男性腺体含有更多的锌，但年轻男性中锌的浓度高于女性。本研究还表明，人体垂体前叶中铜含量存在与年龄相关的差异，因为15至45岁人群的垂体前叶含铜量比年轻或年长者的垂体前叶多25%。在男性中观察到相反的模式。对于铜、铁、锰和硒等元素，人体垂体前叶中的含量是其他内分泌器官所述含量的1.6至2倍。
