巴氯芬和氨基氧乙酸对刺激多巴胺能系统药物作用的影响。
The effect of baclofen and aminooxyacetic acid on the action of drugs stimulating the dopaminergic system.
作者信息
Sypniewska M
出版信息
Pol J Pharmacol Pharm. 1978 Nov-Dec;30(6):755-66.
PMID:573471
Abstract
Baclofen and aminooxyacetic acid (AOAA) depressed the explorative and locomotor activity in rats. Baclofen, but not AOAA, decreased the locomotor stimulation, produced by apomorphine. Both compounds did not affect hyperactivity, induced by D, L-amphetamine, amantadine and methylphenidate. Neither baclofen nor AOAA influenced stereotypy induced by the above four substances.
摘要
巴氯芬和氨氧乙酸（AOAA）抑制大鼠的探索性和运动活性。巴氯芬可降低阿扑吗啡引起的运动兴奋，但AOAA无此作用。这两种化合物均不影响由D，L-苯丙胺、金刚烷胺和哌醋甲酯引起的多动。巴氯芬和AOAA均不影响上述四种物质诱导的刻板行为。
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