Schill W B
Arch Androl. 1979 Mar;2(2):163-70. doi: 10.3109/01485017908987308.
Ninety subfertile men with idiopathic oligozoospermia were treated orally with either 600 units porcine pancreatic kallikrein or placebo daily for 7 wk. Kallikrein caused an increase in the number of spermatozoa (3.1 X 10(7) with a maximum 2--3 mo after onset of therapy. There was an improvement of the quantitative and qualitative sperm motility with a maximum at the end of treatment. Five months after onset of therapy, pretreatment values were regained. There were no major side effects. Conception rates within a period of 1 yr were 16% for placebo and 38% for kallikrein.
90名患有特发性少精子症的不育男性每天口服600单位猪胰激肽释放酶或安慰剂，持续7周。激肽释放酶使精子数量增加（治疗开始后最多2 - 3个月时为3.1×10⁷）。治疗结束时精子活力在数量和质量上都有改善且达到最大值。治疗开始5个月后，恢复到治疗前水平。没有严重副作用。1年内安慰剂组的受孕率为16%，激肽释放酶组为38%。
