Eroğlu L, Koyuncuoğlu H
Pol J Pharmacol Pharm. 1979 Mar-Apr;31(2):83-8.
The mice (Balb/C strain) given 2% aspartic acid in 5% saccharose solution or only saccharose solution (p. os) starting 12 hr before the sc morphine pellet implantation until the removal of pellet were rendered physically morphine dependent. During the development of morphine dependence and after the removal of pellets (on 3-d day) spontaneous motor activity and analgesic threshold were measured as reliable abrupt withdrawal signs. Aspartic acid prevented to some extent the appearance of symptoms of physical morphine dependence.
在皮下植入吗啡丸前12小时开始，给（Balb/C品系）小鼠经口喂服含2%天冬氨酸的5%蔗糖溶液或仅喂服蔗糖溶液，直至取出吗啡丸，使小鼠产生身体对吗啡的依赖性。在吗啡依赖性形成过程中以及取出吗啡丸后（第3天），测量自发运动活性和镇痛阈值，作为可靠的突然戒断体征。天冬氨酸在一定程度上可防止身体吗啡依赖性症状的出现。
