脯氨酸类似物3,4-脱氢-DL-脯氨酸诱导雏鸡和小鼠出现逆行性遗忘。

Retrograde amnesia in chicks and mice induced by 3,4-dehydro-DL-proline, a proline analog.

作者信息

Davis J L, Cherkin A

出版信息

Pharmacol Biochem Behav. 1979 May;10(5):643-5. doi: 10.1016/0091-3057(79)90314-9.

Abstract

L-proline induces retroactive amnesia without causing brain seizures or isoelectric activity. 3,4-dehydro-DL-proline, a proline analog containing a double-bond in the 5-membered ring, has similar effects at a smaller dose. Three experiments describe the amnestic qualities of 3,4-dehydro-DL-proline in a chick memory paradigm, the retrograde quality of this amnesia, and its existence in a mammalian (mouse) preparation. Finally, EEG records show that chicks injected with amnestic doses of 3,4-dehydro-DL-proline do not exhibit seizure spiking or abnormal electrical activity.

摘要

L-脯氨酸可诱发逆行性失忆，而不会引发脑部癫痫发作或等电位活动。3,4-脱氢-DL-脯氨酸是一种在五元环中含有双键的脯氨酸类似物，在较小剂量下具有类似作用。三项实验描述了3,4-脱氢-DL-脯氨酸在雏鸡记忆范式中的失忆特性、这种失忆的逆行性特性以及它在哺乳动物（小鼠）实验中的存在情况。最后，脑电图记录显示，注射失忆剂量的3,4-脱氢-DL-脯氨酸的雏鸡未出现癫痫尖峰或异常电活动。