D'Amour M L, Shahani B T, Young R R, Bird K T
Neurology. 1979 Dec;29(12):1600-4. doi: 10.1212/wnl.29.12.1600.
Motor conduction velocities of median, ulnar, peroneal, and tibial nerves and sensory conduction velocities of median and ulnar nerves were studied in 30 alcoholic subjects and a similar group of control subjects. The results were compared to sural nerve conduction velocities and late response latencies (H reflex, F response). The latter two techniques improved the diagnostic yield by 20%: Whereas 73% of our patients showed an abnormality of conduction with conventional techniques, 93% had an abnormality of sural nerve conduction, late response latencies, or both. Abnormalities of motor and sensory conduction, which were more prominent in the lower limbs than the arms, could be documented in patients who did not have any clinical evidence of peripheral neuropathy. The electrophysiologic studies performed in the present study suggest that "axonal degeneration" is the underlying pathologic process in alcoholic peripheral nerve disease.
对30名酒精中毒患者和一组类似的对照受试者进行了正中神经、尺神经、腓总神经和胫神经的运动传导速度以及正中神经和尺神经的感觉传导速度研究。将结果与腓肠神经传导速度和迟发反应潜伏期（H反射、F反应）进行比较。后两种技术使诊断率提高了20%：使用传统技术时，我们的患者中有73%表现出传导异常，而93%的患者存在腓肠神经传导、迟发反应潜伏期异常或两者皆有。在没有任何周围神经病变临床证据的患者中，也可记录到运动和感觉传导异常，且下肢比上肢更为明显。本研究中进行的电生理研究表明，“轴突变性”是酒精性周围神经疾病的潜在病理过程。
