电生性钠泵对海兔神经元膜电位的作用。
A contribution of an electrogenic Na+ pump to membrane potential in Aplysia neurons.
作者信息
Carpenter D O, Alving B O
出版信息
J Gen Physiol. 1968 Jul;52(1):1-21. doi: 10.1085/jgp.52.1.1.
Abstract
The resting membrane potential (RMP) of Aplysia neurons is very temperature-dependent, and in some cells increases with increasing temperature by as much as 2 mv/ degrees C. RMP at room temperature may significantly exceed the potassium equilibrium potential, which can be determined by measurement of the equilibrium point of the spike after potential. The hyperpolarization on warming is completely abolished by ouabain, replacement of external Na(+) by Li(+), removal of external K(+), and by prolonged exposure to high Ca(++), while it is independent of external chloride but is increased by cocaine (3 x 10(-3)M). In an identified cell that shows a marked temperature dependence of RMP, both the potassium equilibrium potential and the membrane resistance were found to be relatively independent of temperature. The hyperpolarization on warming, which may increase RMP by as much as 50%, can most reasonably be ascribed to the activity of an electrogenic Na(+) pump.
摘要
海兔神经元的静息膜电位（RMP）对温度非常敏感，在某些细胞中，随着温度升高，RMP每摄氏度可增加多达2毫伏。室温下的RMP可能会显著超过钾平衡电位，这可以通过测量动作电位后的平衡点来确定。升温时的超极化可被哇巴因、用Li⁺替代细胞外Na⁺、去除细胞外K⁺以及长时间暴露于高Ca²⁺完全消除，而它与细胞外氯离子无关，但可被可卡因（3×10⁻³M）增强。在一个RMP表现出明显温度依赖性的已鉴定细胞中，发现钾平衡电位和膜电阻相对不受温度影响。升温时的超极化可使RMP增加多达50%，最合理的归因可能是生电Na⁺泵的活动。
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