[单次注射各种蒽环类药物影响下抗体形成细胞动力学的快速变化]

[Rapid change in the dynamics of antibody-forming cells under the influence of a single injection of various anthracyclines].

作者信息

Aleksander S K, Liashenko V A, Shapovalova S P, Malkova I V

出版信息

Antibiotiki. 1979 Dec;24(12):928-32.

Abstract

The dynamics of the titers and number of the antibody forming cells was studied within 26 hours after a single injection of anthracycline to immunized animals at various phases of the immune response. The specificity of the "rapid" effect of anthracyclines suggests that the low differentiated precursors of the antibody forming cells are the main target for the rubomycin effect and the immune competent cells in the state of multiplication and differentiation under the effect of the antigen are the main target for the carminomycin effect. The study was performed with noninbred mice immunized with sheep red cells.

摘要

在免疫反应的不同阶段，对免疫动物单次注射蒽环类药物后26小时内抗体形成细胞的滴度和数量动态进行了研究。蒽环类药物“快速”效应的特异性表明，抗体形成细胞的低分化前体是柔红霉素作用的主要靶点，而在抗原作用下处于增殖和分化状态的免疫活性细胞是洋红霉素作用的主要靶点。该研究是用绵羊红细胞免疫的非近交系小鼠进行的。

相似文献

1

[Rapid change in the dynamics of antibody-forming cells under the influence of a single injection of various anthracyclines].[单次注射各种蒽环类药物影响下抗体形成细胞动力学的快速变化]

Antibiotiki. 1979 Dec;24(12):928-32.

2

[Comparison of the action of carminomycin and rubomycin on the dynamics of the primary and secondary immune responses].[卡米诺霉素和柔红霉素对初次和二次免疫反应动力学作用的比较]

Antibiotiki. 1979 Jun;24(6):449-54.

3

[Effect of rubomycin and carminomycin on antibody formation during the immunization of mice with various antigens].[柔红霉素和洋红霉素对小鼠用各种抗原免疫期间抗体形成的影响]

Antibiotiki. 1978 Oct;23(10):922-6.

4

[Comparison of carminomycin and rubomycin action on the dynamics of the immune response to the T-independent Vi-antigen of S. typhi].[卡米诺霉素和柔红霉素对伤寒杆菌非T依赖性Vi抗原免疫反应动力学的作用比较]

Antibiotiki. 1980 Feb;25(2):140-4.

5

[Effect of carminomycin on the immunological reactivity of the body].

Antibiotiki. 1977 Aug;22(8):734-9.

6

[Immunodepressive action of carminomycin and rubomycin derivatives].[卡米诺霉素和柔红霉素衍生物的免疫抑制作用]

Antibiotiki. 1979 Jul;24(7):521-5.

7

[Functional activity of T- and B-lymphocyte populations after rubomycin and carminomycin exposure].[柔红霉素和洋红霉素暴露后T淋巴细胞和B淋巴细胞群体的功能活性]

Antibiotiki. 1981 Jan;26(1):40-4.

8

[Effect of rubomycin and carminomycin on the delayed hypersensitivity reaction in mice immunized with ram erythrocytes].[柔红霉素和洋红霉素对用绵羊红细胞免疫的小鼠迟发型超敏反应的影响]

Antibiotiki. 1981 Oct;26(10):750-3.

9

[Combined action of rubomycin and diuretics on the induction of antibody synthesis in mice].[柔红霉素与利尿剂联合作用对小鼠抗体合成的诱导]

Antibiotiki. 1980 May;25(5):363-7.

10

[Effect of rubomycin and carminomycin on suppressor cells participating in the regulation of the immune response].[柔红霉素和洋红霉素对参与免疫反应调节的抑制细胞的作用]

Antibiotiki. 1983 Apr;28(4):307-11.

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