[Combined action of rubomycin and diuretics on the induction of antibody synthesis in mice].

The effect of 2 diuretics, diacarb and lasix on the intensity of immunodepressant action of low doses of rubomycin was studied. It was shown that diacarb increased the inhibitory effect of rubomycin on accumulation of the antibody-forming cells in the spleen. This effect was evident by the 3rd, 4th and 7th day after the antigen injection to the mice (the 4th, 5th and 8th day after the last injection of rubomycin). Combined use of rubomycin and diacarb also resulted in a low number of nuclear cells in the spleen as compared to control. Lasix did not increase the immunodepressant effect of rubomycin. Still, when used alone it had a capacity for changing the time course of the immune response development.