Eiler H, Sims M
Am J Vet Res. 1979 Aug;40(8):1100-3.
The dose-response and time-response relationships between injected oxytocin and intramammary pressure were investigated in normal lactating sows. In less than 39 s after 20, 40, or 80 U of oxytocin was given (IM injection), there was a rapid initial increase in intramammary pressure (15 to 27 mm of Hg) which lasted 22 to 32 s. After this initial response, there were secondary oscillations in pressure which lasted approximately 40 minutes (20 U) and up to 60 minutes (40 or 80 U). Changes in intramammary pressure during each oscillation varied between 1 and 5 mm of Hg. Mean values for frequency and amplitude of oscillations and total work (area under the trace) were measured. Compared with response obtained after 20 U of oxytocin was given, responses obtained at the 40-U or 80-U dose level had an increased frequency (150.0% and 249.0%, respectively) and total work (36.6% and 104.4%, respectively), but not amplitude. Thus, there may be some clinical advantage in milk let-down effect when sows are given the larger doses of oxytocin (40 or 80 U). These results indicate that newborn pigs should be allowed to nurse at the same time in which oxytocin is injected.
在正常泌乳母猪中研究了注射催产素与乳内压之间的剂量反应和时间反应关系。在给予20、40或80单位催产素（肌肉注射）后不到39秒，乳内压迅速出现初始升高（15至27毫米汞柱），持续22至32秒。在这个初始反应之后，压力出现继发性振荡，持续约40分钟（20单位）至60分钟（40或80单位）。每次振荡期间乳内压的变化在1至5毫米汞柱之间。测量了振荡的频率、幅度和总功（曲线下面积）的平均值。与给予20单位催产素后获得的反应相比，40单位或80单位剂量水平获得的反应频率分别增加了150.0%和249.0%，总功分别增加了36.6%和104.4%，但幅度没有增加。因此，给母猪较大剂量的催产素（40或80单位）时，在排乳效应方面可能具有一些临床优势。这些结果表明，应在注射催产素的同时让新生仔猪哺乳。
