Bose R, Kumar A, Bhattacharya S K
Neurosci Lett. 1979 Sep;14(1):115-8. doi: 10.1016/0304-3940(79)95355-2.
Morphine hydrochloride (10 mg/kg,i.p.) induced marked catalepsy in rats, which was associated with significantly enhanced striatal acetylcholine levels and reduced cholinesterase activity. Rapid tolerance to morphine-induced catalepsy was noted after twice daily administrations, the tolerance being discernible after the third injection and was complete after the eleventh injection. With the development of tolerance, morphine-induced effects on striatal acetylcholine and cholinesterase were progressively reversed, confirming striatal cholinergic involvement in morphine-induced catalepsy in the rat.
盐酸吗啡（10毫克/千克，腹腔注射）可诱导大鼠出现明显的僵住症，这与纹状体乙酰胆碱水平显著升高和胆碱酯酶活性降低有关。每日给药两次后，可观察到对吗啡诱导的僵住症产生快速耐受性，第三次注射后即可察觉到耐受性，第十一次注射后耐受性完全形成。随着耐受性的发展，吗啡对纹状体乙酰胆碱和胆碱酯酶的作用逐渐逆转，证实纹状体胆碱能系统参与了大鼠吗啡诱导的僵住症。
