Kutscher C L, Yamamoto B K
Pharmacol Biochem Behav. 1979 Dec;11(6):611-6. doi: 10.1016/0091-3057(79)90251-x.
A time-sampling frequency analysis was made of criterion behaviors following injection of 2.5--10 mg/kg dosages of p-chloroamphetamine (PCA). Stereotypic behaviors (forepaw treading, circling, head weaving and inching) increased with increasing dosages and normal behaviors (grooming, rearing, and instances of inactivity) decreased. Composite scores of stereotypic behavior were a positive, linear function of PCA dosage. Composite scores of normal behavior showed near maximal inhibition at 5 mg/kg. Splayed hindlimbs is a reliable and sensitive indicator of PCA action, but vocalization, tremors, diarrhea and autonomic signs are not. Preinjection of PCA strongly attenuated the PCA-induec syndrome, as expected, since the preinjection should deplete brain serotonin and reduce the amount released by the second PCA injection.
对注射2.5 - 10mg/kg剂量对氯苯丙胺（PCA）后的标准行为进行了时间采样频率分析。刻板行为（前爪踩踏、转圈、头部摆动和缓慢移动）随剂量增加而增加，正常行为（梳理毛发、直立和静止不动的情况）则减少。刻板行为的综合评分是PCA剂量的正线性函数。正常行为的综合评分在5mg/kg时显示出接近最大程度的抑制。后肢张开是PCA作用的可靠且敏感指标，但发声、震颤、腹泻和自主神经体征则不是。如预期的那样，PCA预注射强烈减弱了PCA诱导的综合征，因为预注射应该耗尽脑血清素并减少第二次PCA注射释放的量。
