新型精神活性药物7-氯-2,3-二氢-1-甲基-5-苯基-1H-1,4-苯并二氮杂䓬（Ro 5-4556）在人体中的代谢与药代动力学 - Suppr

Suppr

超能文献

[Metabolism and pharmacokinetics of the new psychoactive drug 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine (Ro 5-4556) in man].

作者信息

Rieder J, Rentsch G

出版信息

Arzneimittelforschung. 1968 Dec;18(12):1545-56.

PMID:5756247

Abstract

摘要

相似文献

[Metabolism and pharmacokinetics of the new psychoactive drug 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine (Ro 5-4556) in man].新型精神活性药物7-氯-2,3-二氢-1-甲基-5-苯基-1H-1,4-苯并二氮杂䓬（Ro 5-4556）在人体中的代谢与药代动力学

Arzneimittelforschung. 1968 Dec;18(12):1545-56.

[Pharmacokinetics and metabolism of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepine-2-one and its hemisuccinate in human].

Arzneimittelforschung. 1969 Oct;19(10):1652-6.

[Metabolism of 7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid, monopotassium salt, monopotassium hydroxide (mendon)].

Nihon Yakurigaku Zasshi. 1973 May;69(3):419-28. doi: 10.1254/fpj.69.419.

Disposition of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in humans. Determination of the drug by electron capture gas chromatography.7-氯-5-（邻氯苯基）-1,3-二氢-3-羟基-2H-1,4-苯并二氮杂卓-2-酮（劳拉西泮）在人体内的处置。通过电子捕获气相色谱法测定该药物。

Arzneimittelforschung. 1971 Jul;21(7):1055-9.

Prazepam metabolism by man.

Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.

[Thin-layer chromatographic-spectrophotofluorimetric determination of 7-chlor-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine (medazepam)].

Arzneimittelforschung. 1969 May;19(5):740-1.

Prazepam metabolism by dogs.

J Pharm Sci. 1969 Aug;58(8):960-2. doi: 10.1002/jps.2600580811.

[Quantitative identification of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepine-2-one in plasma at single and prolonged administration].

Arzneimittelforschung. 1969 Oct;19(10):1659-62.

[Analysis of benzodiazepines using gas chromatography, 1. Medazepam and its metabolites].

Arzneimittelforschung. 1973 Apr;23(4):614-6.

Metabolites of demoxepam, a chlordiazepoxide metabolite, in man.

J Pharm Sci. 1972 Jan;61(1):123-5. doi: 10.1002/jps.2600610128.

引用本文的文献

A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites.一种用于研究苯二氮䓬类药物及其活性代谢产物在人血浆中的亲和力及其受体结合活性的放射受体测定法。

Br J Clin Pharmacol. 1982 Apr;13(4):561-5. doi: 10.1111/j.1365-2125.1982.tb01422.x.

Identification of oxaxepam and lorazepam glucuronides by chemical ionization mass spectrometry.通过化学电离质谱法鉴定奥沙西泮和劳拉西泮葡萄糖醛酸苷。

Experientia. 1973 Jun 15;29(6):653-5. doi: 10.1007/BF01944753.

[The influence of plasma protein binding on distribution and pharmacological activity of tranquilizers of the benzodiazepine group (author's transl)].血浆蛋白结合对苯二氮䓬类镇静剂分布及药理活性的影响（作者译）

Klin Wochenschr. 1977 Feb 1;55(3):105-10. doi: 10.1007/BF01490237.

Effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines.

Naunyn Schmiedebergs Arch Pharmacol. 1976 Jul;294(1):91-7. doi: 10.1007/BF00692789.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验