乙醇对血小板血栓素合成的影响。
The effect of ethanol on thromboxane synthesis by blood platelets.
作者信息
Pennington S N, Smith C P
出版信息
Prostaglandins Med. 1979 Jan;2(1):43-50. doi: 10.1016/s0161-4630(79)80007-5.
The synthesis of thromboxane A2 (measured as TXB2) by blood platelets in the presence of ethanol and in platelets from animals dosed chronically with ethanol has been examined. Neither acute nor chronic exposure of guinea pig platelets to ethanol altered thromboxane synthesis. Measurement of total products indicated that neither fatty acid cyclooxygenase nor platelet lipoxygenase was influenced by blood ethanol levels generally associated with intoxication. In human platelets, very high levels of ethanol inhibited thromboxane synthesis in a dose related manner. These results are contrary to reports that high doses of ethanol stimulate arachidonate cyclooxygenation.
已对血小板在乙醇存在的情况下以及在长期给予乙醇的动物的血小板中血栓素A2（以TXB2衡量）的合成进行了研究。豚鼠血小板无论是急性还是慢性暴露于乙醇，均未改变血栓素的合成。对总产物的测量表明，通常与中毒相关的血液乙醇水平既不影响脂肪酸环氧化酶，也不影响血小板脂氧合酶。在人类血小板中，非常高的乙醇水平以剂量相关的方式抑制血栓素的合成。这些结果与高剂量乙醇刺激花生四烯酸环氧化的报道相反。
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