Bencko V, Brezina M, Benes B, Cikrt M
J Hyg Epidemiol Microbiol Immunol. 1979;23(4):361-7.
Penetration of beryllium through the placenta and its distribution in the organs after intravenous administration of BeCl2 in a dose of 0.1 mg/kg was studied in a series of experiments on ICR SPF mice. To trace the fate of beryllium, an isotope in the form of 7BeCl2 in an amount of 111kBq per animal was used. This dose was administered to a group of females before fertilization, on the 7th and 14th day of pregnancy, and to control animals. The animals were killed on the 18th to 19th day of pregnancy and the content of beryllium in the foetuses and its distribution in the organs of the mothers were determined by measuring activity. It has been found that beryllium penetrates through the placenta with difficulty, however, part of the dose administered circulated in the blood long enough for Be to penetrate the foetuses. Of interest is the finding that beryllium in the dose administered influenced the number of foetuses of the exposed females. This finding deserves detailed evaluation in the test of dominant lethal mutations.
在一系列针对ICR无特定病原体小鼠的实验中，研究了静脉注射剂量为0.1mg/kg的氯化铍后，铍穿过胎盘的情况及其在器官中的分布。为追踪铍的去向，使用了每只动物含111kBq的7BeCl2形式的同位素。该剂量在受精前、怀孕第7天和第14天给予一组雌性动物，并给予对照动物。在怀孕第18至19天处死动物，通过测量放射性来确定胎儿中的铍含量及其在母体器官中的分布。已发现铍难以穿过胎盘，然而，所给予剂量的一部分在血液中循环了足够长的时间，以使铍能够穿透胎儿。有趣的是，所给予剂量的铍影响了受暴露雌性动物的胎儿数量。这一发现值得在显性致死突变试验中进行详细评估。
