St John D J, Yeomans N D, Bourne C A, de Boer W G
Arch Pathol Lab Med. 1977 Jan;101(1):44-8.
Stomachs of 22 rats treated with aspirin for six months were examined histologically at times ranging from 6 to 18 months after completion of treatment. Healed chronic gastric ulcers were found in 20 rats. Glandular dysplasia was present at the sites of healed ulcers in 12 rats, the glands extending into the submucosa, muscularis propria, and even subserosal fat. The apparent lack of progression with time and the absence of metastases suggest that the changes are not neoplastic but are a consequence of repeated injury and regeneration, with entrapment of glands below the level of the muscularis mucosae. The lesions in the aspirin-treated animals closely resemble those of gastritis cystica polyposa and colitis cystica profunda in the human subject.
对22只服用阿司匹林六个月的大鼠的胃进行组织学检查，检查时间为治疗结束后6至18个月。在20只大鼠中发现了愈合的慢性胃溃疡。12只大鼠愈合溃疡部位出现腺发育异常，腺体延伸至黏膜下层、固有肌层，甚至浆膜下脂肪。随着时间推移明显缺乏进展且无转移，这表明这些变化不是肿瘤性的，而是反复损伤和再生的结果，黏膜肌层以下腺体陷入其中。服用阿司匹林的动物中的病变与人类的息肉样囊状胃炎和深部囊状结肠炎的病变非常相似。
