大鼠血浆及各种阳离子对桑色素抗蜂毒活性的影响。
Influence of rat plasma and of various cations on the anti-eledoisin activity of morin.
作者信息
Gascon A L
出版信息
Br J Pharmacol. 1969 Jan;35(1):187-96. doi: 10.1111/j.1476-5381.1969.tb07979.x.
Abstract
- The musculotropic activity of eledosin on the isolated guinea-pig ileum is antagonized by morin, a flavonoid derivative.2. The anti-eledoisin activity of morin is abolished by fresh rat plasma and by deproteinized rat plasma, but not by deionized plasma.3. Cupric acetate can restore the inhibitory property of the deionized plasma and can also inactivate morin.4. This effect of rat plasma and of cupric acetate is inhibited by (-)-penicill-amine and by N-acetyl-(+/-)-penicillamine.5. It is concluded that, when in contact with rat plasma, morin is probably inactivated as a consequence of the formation of a complex with the plasma copper.
摘要
一种黄酮类衍生物桑色素可拮抗依来多辛对离体豚鼠回肠的促肌活性。
桑色素的抗依来多辛活性可被新鲜大鼠血浆和脱蛋白大鼠血浆消除，但不能被去离子血浆消除。
醋酸铜可恢复去离子血浆的抑制特性，也可使桑色素失活。
（-）-青霉胺和N-乙酰-（±）-青霉胺可抑制大鼠血浆和醋酸铜的这种作用。
得出的结论是，当与大鼠血浆接触时，桑色素可能因与血浆铜形成复合物而失活。
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