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苯氧苄胺对心肌梗死所致休克的作用。

Effects of phenoxybenzamine in shock due to myocardial infarction.

作者信息

Riordan J F, Walters G

出版信息

Br Med J. 1969 Jan 18;1(5637):155-8. doi: 10.1136/bmj.1.5637.155.

DOI:10.1136/bmj.1.5637.155
PMID:5762277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1982318/
Abstract

Treatment of cardiogenic shock with vasodilator drugs has been advocated on the basis of experimental work showing that a fall in peripheral resistance allows the cardiac output to increase without any increase in cardiac work.Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine. In two cases there was dramatic improvement in the signs and symptoms of shock, but in six of the seven cases there were severe adverse effects on respiration, including the development of wheezing and rales and rhonchi.

摘要

基于实验研究结果，有人主张使用血管扩张药物治疗心源性休克，这些研究表明外周阻力下降可使心输出量增加，而心脏做功并无增加。七名继发于心肌梗死的休克患者接受了苯氧苄胺治疗。其中两例休克的体征和症状有显著改善，但七例中有六例出现了严重的呼吸不良反应，包括喘息、啰音和哮鸣音。

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引用本文的文献

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Advances in acute coronary care. 2.急性冠脉护理进展。2.
J R Coll Gen Pract. 1970 Sep;20(98):153-62.

本文引用的文献

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A CORONARY PROGNOSTIC INDEX FOR GRADING THE SEVERITY OF INFARCTION.一种用于评估梗死严重程度的冠状动脉预后指数。
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8
Dimensional relationships in dye-dilution curves from humans and dogs, with an empirical formula for certain troublesome curves.人类和狗的染料稀释曲线中的维度关系，以及针对某些棘手曲线的经验公式。
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Results of a general hospital coronary care service.一家综合医院冠心病护理服务的结果。
Br Med J. 1968 Mar 30;1(5595):830-3. doi: 10.1136/bmj.1.5595.830.

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