Analysis of homatropine methylbromide dosage forms.
作者信息
Hanna S, Rosen M, Rasero L, Lachman L
出版信息
J Pharm Sci. 1977 Jan;66(1):123-4. doi: 10.1002/jps.2600660135.
PMID:576237
Abstract
A stability-indicating method of analysis of homatropine methylbromide in pharmaceutical formulations was developed. This method is based on the formation of a picric acid-quaternary ammonium complex, which is adsorbed on acid-washed diatomaceous earth in alkaline media followed by on-column chloroform extraction. The picrate complex is measured spectrophotometrically at 365 nm. The method was selective for homatropine methylbromide in that there was no interference from its major hydrolytic decomposition products, tropinium methylbromide and mandelic acid.
摘要
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