Duffy G P
Br Med J. 1969 Feb 15;1(5641):407-9. doi: 10.1136/bmj.1.5641.407.
Study of 30 patients with raised intracranial pressure whose condition worsened after lumbar puncture emphasizes the danger of carrying this out in the presence of raised intracranial pressure. In half the cases deterioration was immediate and dramatic, and in the other half it occurred within 12 hours. Probably a tentorial or cerebellar pressure cone, or both, had formed before lumbar puncture, and the procedure made this worse and caused the clinical deterioration.A history of progressive headache associated with mental changes, and the development and progression of localizing neurological signs were the two features suggestive of varied intracranial pressure found most constantly in this series. A good quality plain x-ray film is important in the diagnosis of this condition.
对30例颅内压升高患者进行的研究表明,腰椎穿刺后病情恶化,这凸显了在颅内压升高情况下进行腰椎穿刺的危险性。半数病例病情立即急剧恶化,另一半在12小时内出现恶化。腰椎穿刺前可能已经形成小脑幕或小脑压力锥,或两者皆有,而该操作使情况恶化并导致临床病情恶化。在本系列研究中,最常发现的提示颅内压变化的两个特征是:伴有精神改变的进行性头痛病史,以及定位性神经体征的出现和进展。高质量的普通X线片对该病的诊断很重要。