Zeya H I, Spitznagel J K
Science. 1969 Mar 7;163(3871):1069-71. doi: 10.1126/science.163.3871.1069.
The cationic, antibacterial proteins of polymorphonuclear leukocytes are associated with a unique subcellular particle that is separable through zonal density gradient centrifugation from acid phosphatase-containing particles as well as from particles that contain alkaline phosphatase and lysozyme. Normal macrophages, macrophages stimulated by bacillus Calmette-Guérin, and liver cells lack this particle and the associated group of cationic proteins. Particles physically and biochemically similar to slower sedimenting enzyme-rich particles of polymorphonuclear leukocytes are shared by all the tlhree cell types.
多形核白细胞的阳离子抗菌蛋白与一种独特的亚细胞颗粒相关联，这种颗粒可通过区带密度梯度离心法与含酸性磷酸酶的颗粒以及含有碱性磷酸酶和溶菌酶的颗粒分离。正常巨噬细胞、卡介苗刺激的巨噬细胞和肝细胞缺乏这种颗粒及相关的阳离子蛋白组。所有这三种细胞类型都具有与多形核白细胞沉降较慢的富含酶的颗粒在物理和生化性质上相似的颗粒。
