Hanaoka M, Suzuki S, Hotchin J
Science. 1969 Mar 14;163(3872):1216-9. doi: 10.1126/science.163.3872.1216.
Selective destruction of small lymphocytes in the thymusdependent areas of lymph nodes and thymocytes was observed in mice infected with lymphocytic choriomeningitis virus. These changes were clearly evident in lymphoid and splenic tissue 3 days after infection and in the thymus by day 7. The destructive changes paralleled growth of the virus in these organs. The findings show that infection with lymphocytic choriomeningitis virus can temporarily cause the equivalent effect of neonatal thymectomy, that is, a "viral thymectomy," which appears to be related to the ability of this virus to cause persistent infection.
在感染淋巴细胞性脉络丛脑膜炎病毒的小鼠中，观察到淋巴结胸腺依赖区的小淋巴细胞和胸腺细胞被选择性破坏。感染后3天，这些变化在淋巴组织和脾脏组织中明显可见，到第7天在胸腺中也明显可见。这些破坏性变化与病毒在这些器官中的生长平行。研究结果表明，感染淋巴细胞性脉络丛脑膜炎病毒可暂时导致相当于新生期胸腺切除的效果，即“病毒性胸腺切除”，这似乎与该病毒引起持续性感染的能力有关。
