• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity.

作者信息

Krenitsky T A, Papaioannou R, Elion G B

出版信息

J Biol Chem. 1969 Mar 10;244(5):1263-70.

PMID:5767308
Abstract
摘要

相似文献

1
Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity.人次黄嘌呤磷酸核糖基转移酶。I. 纯化、性质及特异性
J Biol Chem. 1969 Mar 10;244(5):1263-70.
2
Human hypoxanthine phosphoribosyltransferase. II. Kinetics and chemical modification.
J Biol Chem. 1969 Mar 10;244(5):1271-7.
3
INHIBITION OF PRUINE PHOSPHORIBOSYLTRANSFERASES OF EHRLICH ASCITES-TUMOUR CELLS BY 6-MERCAPTOPURINE.6-巯基嘌呤对艾氏腹水癌细胞嘌呤磷酸核糖转移酶的抑制作用
Biochem J. 1965 Jan;94(1):64-70. doi: 10.1042/bj0940064.
4
Substrate binding specificity and properties of inosine monophosphate: pyrophosphate phosphoribosyltransferase (EC 2.4.2.8) from Brewers yeast.
Biochemistry. 1969 Feb;8(2):603-8. doi: 10.1021/bi00830a021.
5
INHIBITION BY 6-MERCAPTOPURINE OF PURINE PHOSPHORIBOSYLTRANSFERASES FROM EHRLICH ASCITES-TUMOUR CELLS THAT ARE RESISTANT TO THE DRUG.6-巯基嘌呤对来自抗该药物的艾氏腹水瘤细胞的嘌呤磷酸核糖转移酶的抑制作用。
Biochem J. 1965 Jan;94(1):71-4. doi: 10.1042/bj0940071.
6
Kinetic studies of hypoxanthine-guanine phosphoribosyltransferase.次黄嘌呤-鸟嘌呤磷酸核糖转移酶的动力学研究
J Biol Chem. 1968 May 25;243(10):2514-22.
7
Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties.
Biochemistry. 1972 Dec 5;11(25):4723-31. doi: 10.1021/bi00775a014.
8
Studies on human erythrocyte IMP: pyrophosphate phosphoribosyltransferase.关于人红细胞肌苷酸：焦磷酸磷酸核糖基转移酶的研究。
Eur J Biochem. 1970 Aug;15(2):367-73. doi: 10.1111/j.1432-1033.1970.tb01017.x.
9
Hypoxanthine-guanine phosphoribosyltransferase: further evidence for the identity of the binding sites for hypoxanthine and guanine.
Can J Biochem. 1969 Jan;47(1):69-71. doi: 10.1139/o69-012.
10
Hypoxanthine phosphoribosyltransferase and guanine metabolism of adenocarcinoma 755 cells.
Biochem Pharmacol. 1970 Feb;19(2):545-57. doi: 10.1016/0006-2952(70)90211-x.

引用本文的文献

1
Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis.新型疗法治疗炎症性皮肤疾病（包括银屑病）的临床前疗效显著且无毒副作用。
Biomed Res Int. 2023 Jul 11;2023:4878774. doi: 10.1155/2023/4878774. eCollection 2023.
2
Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites.系统性宿主炎症诱导疟原虫在特定阶段的转录组修饰和更缓慢的成熟。
mBio. 2023 Aug 31;14(4):e0112923. doi: 10.1128/mbio.01129-23. Epub 2023 Jul 14.
3
Pharmacogenetics of thiopurines.
硫唑嘌呤的药物遗传学
Cancer Drug Resist. 2019 Jun 19;2(2):256-270. doi: 10.20517/cdr.2019.004. eCollection 2019.
4
Perfecting a high hypoxanthine phosphoribosyltransferase activity-uricase KO mice to test the effects of purine- and non-purine-type xanthine dehydrogenase (XDH) inhibitors.完善高次黄嘌呤磷酸核糖基转移酶活性-尿酸氧化酶基因敲除小鼠，以测试嘌呤型和非嘌呤型黄嘌呤脱氢酶（XDH）抑制剂的效果。
Br J Pharmacol. 2020 May;177(10):2274-2285. doi: 10.1111/bph.14978. Epub 2020 Feb 18.
5
Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics.别嘌醇，黄嘌呤氧化酶抑制剂，通过激活嘌呤补救途径和恢复细胞能量代谢来减少巨噬细胞中 NLRP3 依赖性炎症。
Sci Rep. 2019 Nov 21;9(1):17314. doi: 10.1038/s41598-019-53965-x.
6
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.布氏锥虫腺嘌呤磷酸核糖基转移酶介导腺嘌呤回收和氨喋呤敏感性，但不介导腺嘌呤毒性。
Int J Parasitol Drugs Drug Resist. 2013 Dec 19;4(1):55-63. doi: 10.1016/j.ijpddr.2013.12.001. eCollection 2014 Apr.
7
Pyrazolopyrimidine metabolism in parasitic protozoa.吡唑并嘧啶代谢在寄生原生动物中。
Pharm Res. 1984 Sep;1(5):194-203. doi: 10.1023/A:1016365128531.
8
Prolonged fasting increases purine recycling in post-weaned northern elephant seals.断乳后北方象海豹长时间禁食会增加嘌呤的再循环。
J Exp Biol. 2012 May 1;215(Pt 9):1448-55. doi: 10.1242/jeb.067173.
9
Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer.微 RNA-155（miR-155）诱导的突变活性将炎症与癌症联系起来。
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4908-13. doi: 10.1073/pnas.1101795108. Epub 2011 Mar 7.
10
The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.磷脂酰肌醇3激酶/蛋白激酶B信号转导通路调控嘌呤核苷酸的合成。
J Biol Chem. 2009 Feb 6;284(6):3521-8. doi: 10.1074/jbc.M806707200. Epub 2008 Dec 8.