Wenn R V, Kamberi I A, Vossough P, Kariminejad M H, Torabee E, Keyvanjah M, Sarberi N
Acta Endocrinol (Copenh). 1977 Apr;84(4):850-9. doi: 10.1530/acta.0.0840850.
Levels of testosterone-oestradiol binding globulin (TeBG) were measured by a precipitation technique in terms of dihydrotestosterone-5alpha (DHT) binding capacity in children, adult males and females, pregnant and hirsute women and women with various trophoblastic disorders. It was found that TeBG levels in children of either sex (1.92 +/- 0.16 mug DHT bound/100 ml serum) approached the normal female range (2.31 +/- 0.11) and were distinctly higher than those of the adult male (1.04 +/- 0.09). In both pregnancy and trophoblastic disease (hydatidiform mole and choriocarcinoma but not metastatic choriocarcinoma) TeBG levels were elevated (17.5 +/- 0.70 and 14.9 +/- 1.49, respectively). In hirsutism TeBG was depressed (1.17 +/- 0.09) and comparable with the levels in normal male subjects. A number of other parameters, HCG, oestradiol-17 beta, testosterone and progesterone were measured and found to be similar to those previously reported in the literature. It appears that TeBG titre might provide an additional index in following the prognosis of trophoblastic disorders, besides HCG measurement.
采用沉淀技术，根据二氢睾酮 - 5α（DHT）结合能力，对儿童、成年男性和女性、孕妇、多毛症女性以及患有各种滋养层疾病的女性进行了睾酮 - 雌二醇结合球蛋白（TeBG）水平的测定。结果发现，无论男女，儿童的TeBG水平（1.92±0.16微克DHT结合/100毫升血清）接近正常女性范围（2.31±0.11），明显高于成年男性（1.04±0.09）。在妊娠和滋养层疾病（葡萄胎和绒毛膜癌，但不包括转移性绒毛膜癌）中，TeBG水平均升高（分别为17.5±0.70和14.9±1.49）。在多毛症患者中，TeBG水平降低（1.17±0.09），与正常男性受试者的水平相当。还测量了一些其他参数，如HCG、雌二醇 - 17β、睾酮和孕酮，发现与文献中先前报道的相似。看来，除了测量HCG外，TeBG滴度可能为跟踪滋养层疾病的预后提供一个额外的指标。
