Habersang S, Leuschner F, von Schlichtegroll A
Arzneimittelforschung. 1977;27(12):45-52.
Only slight toxicity of 7-(3-[2-(3,5-dihydroxyphenyl-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol, Bronchospasmin) was shown in the examination of acute, subacute and chronic trials on various animal species with different modes of application. Slight side-effects noted with high toxically active dosages correspond with those of other well-known beta-sympathicomimetics. No influence on the pre-,peri- and postnatal development could be proven with doses tolerated by the parent animals.
在对不同动物物种进行的急性、亚急性和慢性试验中,采用不同给药方式对7-(3-[2-(3,5-二羟基苯基-2-羟基-乙氨基)]-丙基)-茶碱(瑞普特罗,支气管解痉素)进行检测,结果显示其仅有轻微毒性。高毒活性剂量时出现的轻微副作用与其他知名β-拟交感神经药的副作用相符。在母体动物耐受剂量下,未证实对产前、围产期和产后发育有影响。