Obladen M, Gluck L
J Pediatr. 1977 May;90(5):799-802. doi: 10.1016/s0022-3476(77)81255-9.
The surfactant phospholipids in the tracheal effluent of eight pairs of preterm twins were followed, serially. In four pairs only one of the twins had RDS; in the other four pairs both twins had RDS. Twins with and without RDS had markedly different surfactant phospholipids. Phosphatidylglycerol was absent in all twins with RDS. L/S ratios in tracheal effluent increased after birth in infants with and without RDS. With recovery from RDS, phosphatidylinositol increased. The study helps confirm previous studies of the necessity of the acidic phospholipids, PI and PG, in stabilizing lecithin, as well as that surfactant composition can be independent of gestational age.
对八对早产双胞胎的气管流出物中的表面活性磷脂进行了连续跟踪研究。在四对双胞胎中，只有其中一个患有呼吸窘迫综合征（RDS）；在另外四对双胞胎中，两个都患有RDS。患有和未患有RDS的双胞胎的表面活性磷脂有显著差异。所有患有RDS的双胞胎都缺乏磷脂酰甘油。患有和未患有RDS的婴儿出生后气管流出物中的卵磷脂/鞘磷脂（L/S）比值均升高。随着RDS的恢复，磷脂酰肌醇增加。该研究有助于证实先前关于酸性磷脂（PI和PG）在稳定卵磷脂中的必要性的研究，以及表面活性剂组成可以独立于胎龄的研究。
