与腹部放疗及四联化疗治疗淋巴肉瘤相关的吸收不良
Malabsorption in relation to abdominal irradiation and quadruple chemotherapy for lymphosarcoma.
作者信息
Scarpello J H, Sladen G E
出版信息
Postgrad Med J. 1977 Apr;53(618):219-21. doi: 10.1136/pgmj.53.618.218.
Abstract
A case of severe diarrhoea and steatorrhoea following chemotherapy and abdominal irradiation for lymphosarcoma, is described. Investigations demonstrated bile acid malabsorption, and treatment with cholesytramine and a low fat diet was successful. A questionnaire was sent to thirty-two subjects who had undergone similar treatment for similar pathology and failed to demonstrate any sustained alteration of bowel function. Additionally, nine of these subjects underwent a 14C-glycocholic acid test and no evidence of interruption of the enterohepatic circulation of bile acids was found.
摘要
本文描述了一例因淋巴肉瘤接受化疗和腹部放疗后出现严重腹泻和脂肪泻的病例。检查显示胆汁酸吸收不良，使用消胆胺和低脂饮食治疗取得成功。向32名因类似病理接受类似治疗但未出现任何持续性肠道功能改变的受试者发放了问卷。此外，其中9名受试者接受了14C-甘氨胆酸试验，未发现胆汁酸肠肝循环中断的证据。
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