Clemens J A, Tinsley F C, Fuller R W
Acta Endocrinol (Copenh). 1977 May;85(1):18-24. doi: 10.1530/acta.0.0850018.
The possible participation of dopamine in the neural events that lead to the pro-oestrous surge of luteinizing hormone (LH) was investigated utilizing a dopaminergic ergoline derivative (lergotrile mesylate). Administration of reserpine (2.0 mg/kg, ip) to rats on the day of pro-oestrus depleted brain dopamine and norepinephrine and prevented the LH surge and ovulation. Administration of legotrile mesylate prior to or at the same time as reserpine prevented the inhibitory effects of reserpine on LH release and on ovulation in about half of the animals. When lergotrile mesylate was given on the morning of pro-oestrus, the LH surge was advanced. The results indicate that there is a dopaminergic component in the series of neural events that precede the surge of LH on pro-oestrus, and that the dopaminergic stimulus precedes the LH surge by about 4--5 h.
利用一种多巴胺能麦角碱衍生物（甲磺酸麦角腈）研究了多巴胺在导致促性腺激素释放激素（LH）发情前期激增的神经活动中的可能参与情况。在发情前期当天给大鼠腹腔注射利血平（2.0毫克/千克）会耗尽脑内多巴胺和去甲肾上腺素，并阻止LH激增和排卵。在利血平之前或同时给予甲磺酸麦角腈可在约一半的动物中防止利血平对LH释放和排卵的抑制作用。当在发情前期早晨给予甲磺酸麦角腈时，LH激增提前。结果表明，在发情前期LH激增之前的一系列神经活动中存在多巴胺能成分，并且多巴胺能刺激比LH激增提前约4 - 5小时。
